1. Noctura 400 treatment for diabetic retinopathy (CANDLE): a pilot study to demonstrate and evaluate the care pathway for NHS adoption for routine use to reduce the number of anti-VEGF treatments. https://www.clinicaltrials.gov/ct2/show/NCT02207712 

• I was the PI (Principle Investigator) for this study at Great Western Hospital which was one of the recruitment sites in the UK (along with 17 other participating NHS Trust) for this multicentre randomized trial from 2015-2018

• The recruitment target has been achieved with Swindon being nationally the 4th rank in recruitment out of a total of 18 NHS Trust and data collection. The study was completed by April 2018

 

2. “Effect of Selective Laser Trabeculoplasty on diurnal IOP curve as compared to standard medical treatment”, Nagar M, Shah N, Luhishi EA.

• It was approved by Mid Yorkshire Hospital NHS Trust Ethical Committee – June’05. It was a one-year randomized control trial, which started in July’05 and was completed in Oct-Nov ’06. I was involved in submitting the COREC form for Ethical Committee approval. I was also involved in the recruitment, follow-up, and data collection of research patients.

• In this trial, we concluded that SLT effectively controls the diurnal IOP fluctuation with no statistical difference compared to Latanoprost. The paper on this study has been published in “British Journal of Ophthalmology”

 

3. “A Prospective Study of Amniotic Membrane Transplantation for Ocular Surface Reconstruction of Cornea & Conjunctiva”, Shah N, Sharma M,           Arora I.         

• I undertook a 2 years prospective study, involving 28 patients, in 2000-2002, to evaluate the suitability of Amniotic Membrane Transplantation for the reconstruction of the ocular surface at the Department of Ophthalmology, S.M.S. Medical College Hospital, University, Jaipur, India.

  Conclusion:

• In cases of symptomatic bullous keratopathy, there was a marked decrease in ocular pain following amniotic membrane transplantation.

• Amniotic membrane transplantation is an effective procedure for conjunctival surface reconstruction following trauma, burns, and removal of large disfiguring scars and persistent epithelial defects of the cornea that are refractory to conventional treatment.